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High Intakes of Calcium in Women are Associated with Higher Death Rates

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Objective. To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease.

Design. Prospective longitudinal cohort study.

Setting. Swedish mammography cohort, a population based cohort established in 1987-90.

Participants. 61,433 women (born between 1914 and 1948) followed-up for a median of 19 years.

Main Outcome Measures. Primary outcome measures, identified from registry data, were time to death from all causes (n=11,944) and cause specific cardiovascular disease (n=3862), ischaemic heart disease (n=1932), and stroke (n=1100). ...

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The Clinical Practitioner October 2012

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Medical Psychologists Should Adopt Prescribing Standards That Set Us Apart From Other Prescribers

By John Caccavale, Ph.D. ABMP

Medical psychologists who also prescribe have an opportunity to provide consumers with a clear distinction of why we ought to be primary mental healthcare providers. Doing this is actually quite simple while giving all healthcare providers a model for prescribing that is based on standards developed from the best available science. The following standards are not finite but do give a ...

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Celiac disease may drive ADHD, anxiety, depression and other psych problems

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The Prevalence of Celiac Disease in the United States

The prevalence of celiac disease (CD) in the United States is unknown. We sought to estimate CD prevalence nationwide by using a nationally representative sample.

This study included 7,798 persons aged 6 years or older who participated in the National Health and Nutrition Examination Survey 2009–2010. Serum samples from all participants were tested for immunoglobulin A (IgA) tissue transglutaminase antibodies and, if findings were abnormal, also for IgA endomysial antibodies. Information about prior ...

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Citicoline preserves memory in dementia

August 1, 2012 (Vancouver, British Columbia) — The dietary supplement citicoline, which is sold over the counter in 70 different countries, including the United States, appears to help memory in patients with vascular mild cognitive impairment (VaMCI) and may hinder cognitive deterioration, new research suggests.

Preliminary results from a longitudinal study presented here at the Alzheimer’s Association International Conference (AAIC) 2012 showed that at 9 months, there was a significant difference in Mini–Mental State Examination (MMSE) scores ...

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Metformin safest for prediabetes, diabites, and now mental disorders

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Metformin for Treatment of Antipsychotic-Induced Amenorrhea and Weight Gain in Women With First-Episode Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled Study

Objective:  Data on the treatment of antipsychotic-induced amenorrhea, particularly when occurring with weight gain, are limited. The authors investigated the efficacy and safety of metformin in the treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia.

Method:  Eighty-four women (ages 18–40 years) with first-episode schizophrenia who suffered from amenorrhea during antipsychotic treatment were randomly assigned, in a double-blind study design, ...

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Glycine, low dose lithium are the best treatments for Tourette’s, OCD, ADHD

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Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.

Dysfunction of the γ-aminobutyric acid-ergic system in Tourette syndrome may conceivably underlie the symptoms of motor disinhibition presenting as tics and psychiatric manifestations, such as attention deficit hyperactivity disorder and obsessive-compulsive disorder. The purpose of this study was to identify a possible dysfunction of the γ-aminobutyric acid-ergic system in Tourette patients, especially involving the basal ganglia-thalamo-cortical circuits and the cerebellum. We studied 11 patients with Tourette syndrome and 11 healthy controls. ...

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Avoiding BPA especially important during pregnancy

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Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort

Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior.

Objective: We examined the association between prenatal BPA exposure and child behavior, adjusting for postnatal BPA exposure and hypothesizing sex-specific effects.

Methods: We followed African-American and Dominican women and their children from pregnancy to child’s age 5 years, collecting ...

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Don’t rush to try new drug for impulsiveness/addicitions

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Dopamine, Corticostriatal Connectivity, and Intertemporal Choice
“Value-based decisions optimize behavioral outcomes. Because delayed rewards are discounted, an increased tendency to choose smaller, immediate rewards can lead to suboptimal choice. Steep discounting of delayed rewards (impulsivity) characterizes subjects with frontal lobe damage and behavioral disorders including substance abuse. Correspondingly, animal studies and indirect evidence in humans suggest that lower dopamine in the frontal cortex contributes to steeper discounting by impairing corticostriatal function. To test this hypothesis directly, we performed a randomized, ...

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Clustering of Depression and Inflammation in Adolescents Previously Exposed to Childhood Adversity

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There is mounting interest in the hypothesis that inflammation contributes to the pathogenesis of depression and underlies depressed patients’ vulnerability to comorbid medical conditions.  We studied 147 female adolescents. All were in good health at baseline but at high risk for depression because of family history or cognitive vulnerability.
Multilevel models indicated that childhood adversity promotes clustering of depression and inflammation. Among subjects exposed to high childhood adversity, the transition to depression was accompanied by increases in both CRP and ...

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Effect of vitamin D supplement on depression scores

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This study compared depressive symptoms in participants with low and high serum 25-hydroxyvitamin D (25(OH)D) levels and examined whether supplementation with vitamin D3 would improve symptoms in those with low serum 25(OH)D levels. Participants with low 25(OH)D levels were randomised to either placebo or 40 000 IU vitamin D3 per week for 6 months. Individuals with high serum 25(OH)D levels were used as nested controls. Depressive symptoms were evaluated with the Beck Depression Inventory, Hospital Anxiety and Depression Scale, Seasonal ...

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