GI disorders- Ulcerative colitis, irritable bowel syndrome and irritable bowel disease, all share findings of high homocysteine and low zinc levels.  A new study published in Clin Chim Acta, 2011 July 8  has found significant depletion of plasma melatonin as well. 

CHS recommends:

• Melatonin – 2.5mg every evening
• Folic acid – 500 mcg to 5 mg per day, in divided doses
• Vitamin B12 - 1000 mcg per day orally if under 60, sublingually if 61-80, and 1000 mcg injection monthly if over 80, 
• Zinc (50 mg every other day, with a vitamin C or orange juice)
• Omega 3′s - Super Fisol® 1500 mg. per day 

See more on the science and treatment of GI disorders here http://centerforhealthscience.com/cms.php?page_id=21